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Mi-Ae Lyu Selected Research

BLyS receptor

9/2012Bax345/BLyS: a novel, completely human fusion protein targeting malignant B cells and delivering a unique mitochondrial toxin.
3/2007The growth factor fusion construct containing B-lymphocyte stimulator (BLyS) and the toxin rGel induces apoptosis specifically in BAFF-R-positive CLL cells.
2/2007The rGel/BLyS fusion toxin specifically targets malignant B cells expressing the BLyS receptors BAFF-R, TACI, and BCMA.

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Mi-Ae Lyu Research Topics

Disease

6Neoplasms (Cancer)
01/2012 - 08/2005
4Mantle-Cell Lymphoma (Lymphoma, Mantle Cell)
09/2012 - 02/2007
4Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse)
09/2012 - 02/2007
1Multidrug-Resistant Tuberculosis (Drug-Resistant Tuberculosis)
11/2017
1Infections
11/2017
1Mitochondrial Diseases (Mitochondrial Disease)
09/2012
1Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome)
08/2012
1Hematologic Neoplasms (Hematological Malignancy)
01/2012
1B-Cell Lymphoma (Lymphoma, B Cell)
08/2011
1Pancreatic Neoplasms (Pancreatic Cancer)
02/2008
1B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)
03/2007
1Breast Neoplasms (Breast Cancer)
08/2005

Drug/Important Bio-Agent (IBA)

5rGel-BLyS fusion toxinIBA
08/2012 - 02/2007
3BLyS receptorIBA
09/2012 - 02/2007
2Gelonium multiflorum GEL proteinIBA
01/2012 - 02/2007
2Single-Chain AntibodiesIBA
01/2012 - 02/2008
2Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
02/2008 - 08/2005
1Arginine (L-Arginine)FDA Link
11/2017
1Nitric Oxide (Nitrogen Monoxide)FDA Link
11/2017
1SurvivinIBA
09/2012
1Bortezomib (Velcade)FDA Link
08/2012
1Therapeutic UsesIBA
08/2012
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
01/2012
1Immunotoxins (Immunotoxin)IBA
01/2012
1Pentetic Acid (DTPA)FDA LinkGeneric
08/2011
1Interleukin-6 Receptors (Interleukin 6 Receptor)IBA
11/2010
1NF-kappa B (NF-kB)IBA
05/2010
1CytokinesIBA
02/2008
1Fluorouracil (Carac)FDA LinkGeneric
02/2008
1LigandsIBA
02/2007
1Cytotoxins (Cytolysins)IBA
08/2005

Therapy/Procedure

1Immunotherapy
11/2017
1Therapeutics
02/2008